Colilen IBS 60 Capsules
For the treatment of irritable bowel syndrome, which is characterised by pain, abdominal bloating and intestinal irregularities.
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Colilen IBS is an innovative product for the treatment of irritable bowel syndrome, a condition that manifests with multiple symptoms of differing intensity that vary from person to person.
INSTRUCTIONS
Colilen IBS is indicated for the treatment of irritable bowel syndrome, which is characterised by pain, bloating, distension and abdominal disorders, and may or may not be accompanied by changes in the appearance of faeces and abdominal irregularities (constipation, diarrhoea or an alternation of both).
Thanks to its protective effect, Colilen IBS gradually reduces intestinal ailments. Depending on the intensity of the disorder, treatment should be continued for 2 to 6 weeks and repeated in the event that early symptoms reappear.
HOW IT WORKS
Colilen IBS capsules acts by means of ActiMucin, a patented molecular complex (IT n° 102012902020829) composed of Resins, Polysaccharides and Polyphenols. ActiMucin interacts with the mucosal surface of the intestine, with a physical and mechanical mechanism, forming a protective film that preserves the mucosa from contact with irritants.
Read the warnings and instructions for use carefully.
Instructions for use
Take 2 capsules three times per day, either between meals or before meals. Colilen IBS may also be used in association with other symptomatic treatments during the acute phase of the disorder.
Composition
Functional ingredients: ActiMucin, patented natural molecular complex (IT n° 102012902020829) of resins (from Frankincense), polysaccharides (from Aloe vera) and polyphenols (from Chamomile and Lemon balm), titrated in resins ≥ 18%. Also contains: cumin, microcrystalline cellulose, fennel essential oil. Capsule with plant-based polysaccharides.
Warnings
The product is indicated for ages 8 and up. It is contraindicated in pregnancy and when breastfeeding. Do not use in case of individual hypersensitivity or allergy to one or more components. Store at room temperature, away from heat sources and protected from light. Keep out of reach of children. The expiration date applies when the product is intact and stored properly.
Scientific evidence
EFFICACY CONFIRMED THROUGH USAGE TESTS
An important test has demonstrated the efficacy of Colilen IBS for the statistically significant improvement of symptoms such as pain, bloating and intestinal irregularities, as early as after three weeks of treatment. The usage test was conducted within the setting of ordinary clinical practice at specialised outpatient clinics and included 38 patients (average age 47 years old) who had been diagnosed with IBS in accordance with Rome III criteria.
The results obtained from the usage test are reported below:
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Results for product tolerability, compliance and improved quality of life were also significant.
EFFICACY TEST
The innovative formulation used for Colilen IBS is the result of an in-depth research programme that confirmed efficacy by means of specific tests:
- BARRIER TEST: Colilen IBS has been shown to effectively limit contact between the mucosa and external irritants;
- MUCOADHESION TEST: Colilen IBS adheres effectively to the mucosa even when diluted. This is a necessary condition for the protective effect to be achieved.
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Specific mucoadhesion tests can establish a substance's ability to adhere to the mucosa:
Colilen IBS adheres to 52% of the sites available on the mucosa at a 1:5 dilution and 68% of the sites at a 1:2 dilution.
The experiment was conducted on intestinal cells
Caco-2 isolated from an adenocarcinoma of the colon.
The mucoadhesion of the product was determined by evaluating the product's ability to adhere to the cells and was measured by means of a spectrophotometer.
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Colilen IBS adheres effectively to the mucosae, holding fast for over 2 hours even when subjected to a flow of gastrointestinal juices at a pH of 3.5
- ANTIOXIDANT TEST: COLILEN IBS counteracts the formation of free radicals with an effectiveness of 39%.
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The antioxidant effect was determined by quantifying the formation of free radicals in human cells (Caco-2) exposed to oxidative stress induced by hydrogen peroxide.
The antioxidant effect of the sample studied was evaluated by comparing it to a known water-soluble antioxidant, vitamin C.
